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Home Compound Library Sets Covalent Modifiers

Covalent Modifiers


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Compounds that possess moieties able to interact with biological molecules in the cell have been discarded in DD research projects omitted for quite a long time. Character of the investigation did not allow to suppose direct binding between the target and the agent.
Now molecules with covalent warheads attract researchers’ attention as possible antiviral, antibacterial and anticancer agents.

We have selected the Chemspace Covalent Modifiers library from our Selected Screening set: each compound contains possible covalent binder in it. Binders include alkyl thiols, oxetane rings, sulfonyl halides, Michael acceptors, etc.
Please discover also our Covalent Fragments library which contains compounds that accord with Rule of 3 and possess the possible covalent warhead.

N-[5-(dimethylsulfamoyl)-2-methoxyphenyl]-3-(thiophen-2-yl)prop-2-enamide
CSC027999850
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2-methylpropyl 4-[(2-hydroxycyclohexyl)amino]piperidine-1-carboxylate
CSC028173841
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2-[(1-cyanocyclobutyl)sulfamoyl]benzene-1-sulfonyl fluoride
CSC028296976
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N-cyclopropyl-N'-(3-ethynylphenyl)-N-[(2-methoxyphenyl)methyl]ethanediamide
CSC028310136
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