Structure Info
- Chemspace ID
- CSCS20456218544 (Synthesis)
- IUPAC Name
- 1-phenyl-N-(2,3,6-trifluoro-4-{[3-(2-{[(3S,5S)-5-fluoropiperidin-3-yl]amino}pyrimidin-4-yl)pyridin-2-yl]oxy}phenyl)methanesulfonamide
- Mol formula
- C27H24F4N6O3S
- Mol weight
- 589 Da
- Catalog Number(s)
- HY-161672, T87983, Y4181629
- Copy structure to query editor
- SMILES
- INCHI
- INCHI key
- MOL
Properties
- LogP
- 3.37
- Heavy atoms count
- 41
- Rotatable bond count
- 8
- Number of rings
- 5
- Carbon bond saturation, Fsp3
- 0.222
- Polar surface area (Å)
- 118
- Hydrogen bond acceptors count
- 7
- Hydrogen bond donors count
- 3
- Zoom the structure
- CSCS20456218544
Items Overall 1 item from 1 supplier
| Supplier | Lead time | Ships from | Purity | Pack | Price, € | Qty |
|---|---|---|---|---|---|---|
| Targetmol Chemicals Inc | TBD | United States To: | 90 | 1 mg | POA | |
Description: G-5758 is an orally active IRE1α inhibitor with an IC50 of 38 nM for XBP1s. It is used in studies involving multiple myeloma models [KMS-11], demonstrating good tolerance in rats at oral doses up to 500 mg/kg. G-5758 exhibits pharmacodynamic effects comparable to those induced by IRE1 knockdown.; CAS: 2413455-99-7 | ||||||
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