All
Covalent Modifiers
In-Stock Covalent Modifiers
271 303
Cysteine-targeted Covalent Modifiers
In-Stock Cysteine-Targeted Covalent Modifiers
120 950
Lysine-targeted Covalent Modifiers
In-Stock Lysine-Targeted Covalent Modifiers
43 059
α-Trifluoromethyl Alkene
75
α,β-Unsaturated Amide
α,β-Unsaturated Carbonyl Amide Alkenyl Substituted
32 138
α,β-Unsaturated Carbonyl Amide Alkynyl
2 313
α,β-Unsaturated Carbonyl Amide Vinyl
33 901
α,β-Unsaturated Ester
α,β-Unsaturated Carbonyl Ester Alkenyl Substituted
8 846
α,β-Unsaturated Carbonyl Ester Alkynyl
124
α,β-Unsaturated Carbonyl Ester Vinyl
30
α,β-Unsaturated Ketone
α,β-Unsaturated Carbonyl Ketone Alkenyl Substituted
7 423
α,β-Unsaturated Carbonyl Ketone Alkynyl
10
α,β-Unsaturated Carbonyl Ketone Vinyl
6
α,β-Unsaturated Nitrile
α,β-Unsaturated Nitrile Alkenyl Substituted
60
α,β-Unsaturated Nitrile Alkynyl
2
α,β-Unsaturated Sulfone
α,β-Unsaturated Sulfone Alkenyl Substituted
2 993
α,β-Unsaturated Sulfone Vinyl
252
α,β-Unsaturated Sulfonic Acid
α,β-Unsaturated Sulfonic Acid Alkenyl Substituted
28
α,β-Unsaturated Sulfonic Acid Vinyl
5
α,β-Unsaturated Sulfonyl Amide
α,β-Unsaturated Sulfonyl Amide Alkenyl Substituted
2 223
α,β-Unsaturated Sulfonyl Amide Alkynyl
2
α,β-Unsaturated Sulfonyl Amide Vinyl
1 443
α,β-Unsaturated Thioester
α,β-Unsaturated Thioester Alkenyl Substituted
3
β-Lactam
β-Lactam
2 026
β-Lactone
β-Lactone
119
2-Nitrilodiazine
2-Nitrilodiazine
588
Acyl Halide
Acyl Halide
521
Aldehyde
Common warheads in proteolytic enzyme inhibitors, used in the modification of lysine residues in proteomics.
Aldehyde
18 652
Aldehyde Protected
4 187
Alkenyl Halide
Alkenyl Halide
4 382
Alkyl Halide
Abundant in approved and investigational drugs, cysteine alkylation agents. Used in kinase inhibitors design, mechanism-based inhibitors and much more.
Alkyl Halide
1 732
Alkyne
Alkyne
23 657
Alkynyl Halide
Alkynyl Halide
89
Aziridine
Aziridine
486
Boronic Acid
Warheads for catalytic serine or threonine residues, as exemplified by the approved proteasome inhibitor bortezomib.
Boronic Acid
2 528
Boronic Ester
Boronic Ester
4 797
Carbamate
Carbamate
38 748
Cyanoacrylamide
Cyanoacrylamide
5 955
Disulfide
Disulfide
2 021
Fluorosulfamide
Fluorosulfamide
1 165
Fluorosulfate
Fluorosulfate
520
Imidoyl Halide
Imidoyl Halide
116
Isocyanate
Isocyanate
158
Isothiocyanate
Isothiocyanate
282
Oxetane
Popular warhead to target different types of proteases and glycosidases, cysteine alkylation. Approved oxetane-based drugs – carfilzomib, fosfomycin.
Oxetane
8 832
Oxirane
Oxirane
1 226
Quinone
Quinone ortho
116
Quinone para
1 571
Succinate
Succinate
177
Sulfonyl Fluoride
Addressing the ε-amino group of lysines, targeting tyrosine, activated serine, or threonine residues, reactive toward cysteine and histidine side chains.
Sulfonyl Fluoride
3 661
Thiocarbamate
Thiocarbamate
192
Thioester
Thioester
14
Thiol
Thiol Alkyl
327
Thiol Aryl
16 459
Thiourea
Thiourea
34 087