Compound Library Sets
A quality of a screening library has a crucial importance for success of a drug discovery project. Lead-like compounds are an ideal starting point for such purpose allowing final compounds to remain in drug-like space.
Representative acids have a potential use as peptidomimetics (e.g. RGD), ligands for specific GPCRs (e.g. S1P), Bile receptors in the gut, etc. The set contains unique carboxylic acids with lead-like profiles.
Representative amines have a perspective in the modulation of ion channels GPCRs. There are contains unique primary and secondary amines with lead-like profiles in this set.
Unnatural amino acids
A fast growth of peptidomimetics has encouraged FCH Group to create a representative set of unnatural amino acids. The compounds in this set have lead-like profiles and are a good starting point for a research where unnatural amino acids might be molecules of interest.
This diversity set represents screening compound library by FCH Group, which covers a broad chemical space.
All-purpose fragment library
Fragment-based drug discovery (FBDD) has been a tool for discovering new lead compounds. FBDD develops rapidly: two drugs have already been approved and more than thirty drug candidates have entered the clinic. The library is thought to be a valuable starting point for any FBDD related project.
Fluorine fragment library
19F NMR-based fragment screening has been a method for searching for new F-containing fragment hits. The method is also widely employed as a tool for probing a structure–activity relationship (SAR) in the hit-to-lead pathway. Understanding its significance, chemists at FCH Group have created fluorine fragment library containing molecules with a single-type fluorine group.
“High Fsp3” fragment library
Fragment-like molecules with a high content of sp3-hybridized carbon atoms have been widely employed in recent fragment-based drug discovery projects because «escape from flatland» principle has had a significant influence on searching for new hits. This “high Fsp3” library consists of fragments with mostly saturated carbon atoms.
“Special selection” fragment library
Recent reports have suggested more strict than “rule of 3” criteria for fragment libraries to effectively afford hits. A “special selection” library of molecules that meet these strict criteria is offered.
Fragment-like amines and acids
There are two sets of polar fragments: primary and secondary amines and carboxylic acids. The presence of carboxylic or amino group may serve as a good starting point for growing a fragment to lead molecule.
Amino acid fragments
Here you can find a collection of unnatural amino acids, which have a potential usage in mimicking peptide bonds or the PPI studies. All compounds meet the “rule of 3”.