All
Covalent Modifiers
In-Stock Covalent Modifiers
226 665
Cysteine-targeted Covalent Modifiers
In-Stock Cysteine-Targeted Covalent Modifiers
83 969
Lysine-targeted Covalent Modifiers
In-Stock Lysine-Targeted Covalent Modifiers
69 632
Sets by Warhead: α-Trifluorophenyl Alkene
α-Trifluoromethyl Alkene
50
α,β-Unsaturated Amide
α,β-Unsaturated Carbonyl Amide Alkenyl Substituted
24 222
α,β-Unsaturated Carbonyl Amide Alkynyl
2 213
α,β-Unsaturated Carbonyl Amide Vinyl
23 323
α,β-Unsaturated Ester
α,β-Unsaturated Carbonyl Ester Alkenyl Substituted
8 326
α,β-Unsaturated Carbonyl Ester Alkynyl
270
α,β-Unsaturated Carbonyl Ester Vinyl
133
α,β-Unsaturated Ketone
α,β-Unsaturated Carbonyl Ketone Alkenyl Substituted
5 187
α,β-Unsaturated Carbonyl Ketone Alkynyl
29
α,β-Unsaturated Carbonyl Ketone Vinyl
41
α,β-Unsaturated Nitrile
α,β-Unsaturated Nitrile Alkenyl Substituted
109
α,β-Unsaturated Nitrile Alkynyl
9
α,β-Unsaturated Sulfone
α,β-Unsaturated Sulfone Alkenyl Substituted
593
α,β-Unsaturated Sulfone Alkynyl
1
α,β-Unsaturated Sulfone Vinyl
251
α,β-Unsaturated Sulfonic Acid
α,β-Unsaturated Sulfonic Acid Alkenyl Substituted
16
α,β-Unsaturated Sulfonic Acid Vinyl
6
α,β-Unsaturated Sulfonyl Amide
α,β-Unsaturated Sulfonyl Amide Alkenyl Substituted
1 477
α,β-Unsaturated Sulfonyl Amide Alkynyl
3
α,β-Unsaturated Sulfonyl Amide Vinyl
594
α,β-Unsaturated Thioester
α,β-Unsaturated Thioester Alkenyl Substituted
3
β-Lactam
β-Lactam
1 239
β-Lactone
β-Lactone
32
2-Nitrilodiazine
2-Nitrilodiazine
276
Acyl Halide
Acyl Halide
1 658
Aldehyde
Common warheads in proteolytic enzyme inhibitors, used in the modification of lysine residues in proteomics.
Aldehyde
17 027
Aldehyde Protected
3 937
Alkenyl Halide
Alkenyl Halide
2 992
Alkyl Halide
Abundant in approved and investigational drugs, cysteine alkylation agents. Used in kinase inhibitors design, mechanism-based inhibitors and much more.
Alkyl Halide
1 747
Alkyne
Alkyne
21 683
Alkynyl Halide
Alkynyl Halide
44
Aziridine
Aziridine
614
Boronic Acid
Warheads for catalytic serine or threonine residues, as exemplified by the approved proteasome inhibitor bortezomib.
Boronic Acid
7 215
Boronic Ester
Boronic Ester
7 837
Carbamate
Carbamate
26 077
Cyanoacrylamide
Cyanoacrylamide
2 505
Disulfide
Disulfide
910
Fluorosulfamide
Fluorosulfamide
1 256
Fluorosulfate
Fluorosulfate
499
Imidoyl Halide
Imidoyl Halide
253
Isocyanate
Isocyanate
877
Isothiocyanate
Isothiocyanate
684
Oxetane
Popular warhead to target different types of proteases and glycosidases, cysteine alkylation. Approved oxetane-based drugs – carfilzomib, fosfomycin.
Oxetane
5 915
Oxirane
Oxirane
1 378
Quinone
Quinone ortho
60
Quinone para
565
Succinate
Succinate
275
Sulfonyl Fluoride
Addressing the ε-amino group of lysines, targeting tyrosine, activated serine, or threonine residues, reactive toward cysteine and histidine side chains.
Sulfonyl Fluoride
2 154
Thiocarbamate
Thiocarbamate
97
Thioester
Thioester
14
Thiol
Thiol Alkyl
1 106
Thiol Aryl
12 223
Thiourea
Thiourea
10 482