Structure Info
- Chemspace ID
- CSCS20621659484 (Synthesis)
- IUPAC Name
- [3-({4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}oxy)prop-1-yn-1-yl]({1,3,5-triaza-7λ⁵-phosphatricyclo[3.3.1.1³,⁷]decan-7-yl})gold
- Mol formula
- C24H24AuClFN6O2P
- Mol weight
- 711 Da
- Catalog Number(s)
- HY-168492
- Copy structure to query editor
- SMILES
- INCHI
- INCHI key
- MOL
Properties
- LogP
- 3.36
- Heavy atoms count
- 36
- Rotatable bond count
- 8
- Number of rings
- 6
- Carbon bond saturation, Fsp3
- 0.333
- Polar surface area (Å)
- 66
- Hydrogen bond acceptors count
- 8
- Hydrogen bond donors count
- 1
- Zoom the structure
- CSCS20621659484
Items Overall 1 item from 1 supplier
| Supplier | Lead time | Ships from | Purity | Pack | Price, € | Qty |
|---|---|---|---|---|---|---|
| MedChemExpress | TBD | United States To: | 90 | 1 mg | POA | |
Description: Names: TrxR/EGFR-IN-1; Product Description: TrxR/EGFR-IN-1 (Compound L1Au2) is a TrxR/EGFR inhibitor. TrxR/EGFR-IN-1 is active against both Gefitinib (HY-50895)-sensitive and resistant lung cancers, effectively inhibiting tumor proliferation and promoting apoptosis . TrxR/EGFR-IN-1 promotes the degradation of GPX4 protein through autophagolysosomal and proteasomal pathways, leading to ferroptosis . In addition, TrxR/EGFR-IN-1 can induce endoplasmic reticulum stress and trigger immunogenic cell death. TrxR/EGFR-IN-1 can be used for the research of Gefitinib (HY-50895)-resistant lung cancer .; Target: Apoptosis;EGFR;Ferroptosis;TrxR; CAS: 3038386-42-1 | ||||||
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