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Home CSSS00020668822

Structure Info

Chemspace ID
CSSS00020668822 (In-Stock Screening Compounds)
CAS
1092364-38-9
MFCD
MFCD28044290
IUPAC Name
1-[4-({4-[(3,4-dichloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}oxy)piperidin-1-yl]prop-2-en-1-one
Mol formula
C23H21Cl2FN4O3
Mol weight
491 Da
Catalog Number(s)
21695, 22437, 41360, 141917, 41360-0.05G, 41360-0.25G, A719269, AA0039IJ, AB52199, ACS-1788, ADB3306975002, AG-11220, AG0039LB, AJ52199, AOS0039LB, AR003AAB, AS-74851, B5827, BD328369, BP161454, CD31004614, CSC020668822, D408815, D696906, HY-15730, LAN-B42487, LN01341775, LQT-B42564, M10347, P215770, Q65680, R840257, S7358, SAB-068620, SY235762, T2630, Y0975710, scs-1788

Properties

LogP
4.5
Heavy atoms count
33
Rotatable bond count
6
Number of rings
4
Carbon bond saturation, Fsp3
0.26
Polar surface area (Å)
77
Hydrogen bond acceptors count
6
Hydrogen bond donors count
1

SDS

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C23H21Cl2FN4O3
Zoom the structure
CSSS00020668822
 

Items Overall 16 items from 3 suppliers

SupplierLead timeShips fromPurityPackPrice, $Qty
MedChemExpress10 daysUnited States
To:
995 mg80
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MedChemExpress10 daysUnited States
To:
9910 mg120
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MedChemExpress10 daysUnited States
To:
9950 mg420
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MedChemExpress10 daysUnited States
To:
99100 mg660
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MedChemExpress10 daysUnited States
To:
9910mM/1mL86
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Description: Names: Poziotinib; HM781-36B; NOV120101; Product Description: Poziotinib (HM781-36B) is an orally active, irreversible pan- HER inhibitor, which effectively inhibits EGFR wt , HER-2 and HER-4 with IC 50 s of 3.2, 5.3 and 23.5 nM, respectively. Poziotinib (HM781-36B) also shows excellent inhibitory activities against mutated EGFRs, including EGFR T790M and EGFR L858R/T790M , with IC 50 s of 4.2 and 2.2 nM, respectively. Excellent antitumor activity .; Target: Apoptosis;EGFR; CAS: 1092364-38-9
MedChemExpress EU10 daysSweden
To:
995 mg85
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MedChemExpress EU10 daysSweden
To:
9910 mg126
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MedChemExpress EU10 daysSweden
To:
9950 mg443
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MedChemExpress EU10 daysSweden
To:
99100 mg696
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MedChemExpress EU10 daysSweden
To:
9910mM/1mL91
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Description: Names: Poziotinib; HM781-36B; NOV120101; Product Description: Poziotinib (HM781-36B) is an orally active, irreversible pan-HER inhibitor, which effectively inhibits EGFRwt, HER-2 and HER-4 with IC50s of 3.2, 5.3 and 23.5 nM, respectively. Poziotinib (HM781-36B) also shows excellent inhibitory activities against mutated EGFRs, including EGFRT790M and EGFRL858R/T790M, with IC50s of 4.2 and 2.2 nM, respectively. Excellent antitumor activity; Target: Apoptosis;EGFR; CAS: 1092364-38-9
Targetmol Chemicals Inc30 daysUnited States
To:
981 mg30
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Targetmol Chemicals Inc30 daysUnited States
To:
985 mg64
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Targetmol Chemicals Inc30 daysUnited States
To:
9810 mg98
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Targetmol Chemicals Inc30 daysUnited States
To:
9825 mg196
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Targetmol Chemicals Inc30 daysUnited States
To:
9850 mg347
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Targetmol Chemicals Inc30 daysUnited States
To:
98100 mg546
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Description: Poziotinib (NOV120101)(NOV120101; HM781-36B) is an irreversible HER1/2/4 inhibitor (IC50s: 3/5/23 nM).; CAS: 1092364-38-9
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