Structure Info
- Chemspace ID
- CSSS06657276019 (In-Stock Screening Compounds)
- MFCD
- MFCD35065026
- IUPAC Name
- 5-(19-{4-[3-({4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}oxy)propyl]piperazin-1-yl}-19-oxo-4,7,10,13,16-pentaoxa-1-azanonadecan-1-yl)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
- Mol formula
- C48H58ClFN8O12
- Mol weight
- 993 Da
- Catalog Number(s)
- HY-147941, T74633, Z8999109332
- Copy structure to query editor
- SMILES
- INCHI
- INCHI key
- MOL
Properties
- LogP
- 2.24
- Heavy atoms count
- 70
- Rotatable bond count
- 28
- Number of rings
- 7
- Carbon bond saturation, Fsp3
- 0.479
- Polar surface area (Å)
- 222
- Hydrogen bond acceptors count
- 17
- Hydrogen bond donors count
- 3
- Zoom the structure
- CSSS06657276019
Items Overall 7 items from 3 suppliers
| Supplier | Lead time | Ships from | Purity | Pack | Price, $ | Qty |
|---|---|---|---|---|---|---|
| Enamine Ltd | 5 days | Ukraine To: | 90 | 1 mg | 104 | |
| Enamine Ltd | 5 days | Ukraine To: | 90 | 2 mg | 108 | |
| Enamine Ltd | 5 days | Ukraine To: | 90 | 5 mg | 118 | |
| Enamine Ltd | 5 days | Ukraine To: | 90 | 10 mg | 135 | |
| Enamine Ltd | 5 days | Ukraine To: | 90 | 20 mg | 169 | |
| MedChemExpress | 10 days | United States To: | 95 | 5 mg | 480 | |
Description: Names: MS9427; Product Description: MS9427 is a potent PROTAC EGFR degrader with K d s of 7.1 nM and 4.3 nM for EGFR WT and EGFR L858R, respectively. MS9427 selectively degrades the mutant but not the WT EGFR through both the ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways. MS9427 potently inhibits the proliferation of NSCLC cells. MS9427 can be used for researching anticancer .; Target: EGFR;PROTACs; CAS: 2772613-37-1 | ||||||
| MedChemExpress EU | 10 days | Sweden To: | 95 | 5 mg | 506 | |
Description: Names: MS9427; Product Description: MS9427 is a potent PROTAC EGFR degrader with Kds of 7.1 nM and 4.3 nM for EGFR WT and EGFR L858R, respectively. MS9427 selectively degrades the mutant but not the WT EGFR through both the ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways. MS9427 potently inhibits the proliferation of NSCLC cells. MS9427 can be used for researching anticancer; Target: EGFR;PROTACs; CAS: 2772613-37-1 | ||||||
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