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Home CSSS06744481987

Structure Info

Chemspace ID
CSSS06744481987 (In-Stock Screening Compounds)
IUPAC Name
3-{4-[3-({4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}oxy)propyl]piperazin-1-yl}-N-(8-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}octyl)propanamide
Mol formula
C46H54ClFN8O8
Mol weight
901 Da
Catalog Number(s)
AG0249TQ, BJ58390, HY-141640, T41155

Properties

LogP
4.99
Heavy atoms count
64
Rotatable bond count
22
Number of rings
7
Carbon bond saturation, Fsp3
0.456
Polar surface area (Å)
185
Hydrogen bond acceptors count
13
Hydrogen bond donors count
3

SDS

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C46H54ClFN8O8
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CSSS06744481987
 

Items Overall 4 items from 2 suppliers

SupplierLead timeShips fromPurityPackPrice, $Qty
MedChemExpress10 daysUnited States
To:
991 mg400
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MedChemExpress10 daysUnited States
To:
995 mg1,020
Go to cartEnquire
Description: Names: MS154; Product Description: MS154 is a first-in-class E3 ligase cereblon-recruiting EGFR degrader with K d s of 1.8 nM and 3.8 nM for EGFR WT and EGFR L858R mutants. MS154 potently induces the degradation of mutant but not wild-type EGFR in an E3 ligase-dependent manner in cancer cell lines. MS154 potently inhibits cell proliferation in lung cancer cells (Blue: E3 Ligase ligand (HY-103596); Black: linker (HY-W096167); Pink: EGFR ligand (HY-168305)) .; Target: EGFR;PROTACs; CAS: 2550393-21-8
MedChemExpress EU10 daysSweden
To:
991 mg421
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MedChemExpress EU10 daysSweden
To:
995 mg1,075
Go to cartEnquire
Description: Names: MS154; Product Description: MS154 is a first-in-class E3 ligase cereblon-recruiting EGFR degrader with Kds of 1.8 nM and 3.8 nM for EGFR WT and EGFR L858R mutants. MS154 potently induces the degradation of mutant but not wild-type EGFR in an E3 ligase-dependent manner in cancer cell lines. MS154 potently inhibits cell proliferation in lung cancer cells (Blue: E3 Ligase ligand (HY-103596); Black: linker (HY-W096167); Pink: EGFR ligand (HY-168305)); Target: EGFR;PROTACs; CAS: 2550393-21-8
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