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Home CSSS06744597657

Structure Info

Chemspace ID
CSSS06744597657 (In-Stock Screening Compounds)
IUPAC Name
5-(19-{4-[3-({4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}oxy)propyl]piperazin-1-yl}-19-oxo-4,7,10,13,16-pentaoxa-1-azanonadecan-1-yl)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione; trifluoroacetic acid
Mol formula
C50H59ClF4N8O14
Mol weight
1108 Da
Catalog Number(s)
HY-147941A

Properties

LogP
2.24
Heavy atoms count
77
Rotatable bond count
29
Number of rings
7
Carbon bond saturation, Fsp3
0.48
Polar surface area (Å)
222
Hydrogen bond acceptors count
17
Hydrogen bond donors count
3

SDS

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C50H59ClF4N8O14
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CSSS06744597657
 

Items Overall 10 items from 2 suppliers

SupplierLead timeShips fromPurityPackPrice, €Qty
MedChemExpress10 daysUnited States
To:
995 mg471
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MedChemExpress10 daysUnited States
To:
9910 mg784
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MedChemExpress10 daysUnited States
To:
9925 mg1,618
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MedChemExpress10 daysUnited States
To:
9950 mg2,549
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MedChemExpress10 daysUnited States
To:
99100 mg3,922
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Description: Names: MS9427 (TFA); Product Description: MS9427 TFA is a potent PROTAC EGFR degrader with K d s of 7.1 nM and 4.3 nM for EGFR WT and EGFR L858R, respectively. MS9427 TFA selectively degrades the mutant but not the WT EGFR through both the ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways. MS9427 TFA potently inhibits the proliferation of NSCLC cells. MS9427 TFA can be used for researching anticancer .; Target: EGFR;PROTACs
MedChemExpress EU10 daysSweden
To:
995 mg496
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MedChemExpress EU10 daysSweden
To:
9910 mg826
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MedChemExpress EU10 daysSweden
To:
9925 mg1,704
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MedChemExpress EU10 daysSweden
To:
9950 mg2,686
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MedChemExpress EU10 daysSweden
To:
99100 mg4,132
Go to cartEnquire
Description: Names: MS9427 (TFA); Product Description: MS9427 TFA is a potent PROTAC EGFR degrader with Kds of 7.1 nM and 4.3 nM for EGFR WT and EGFR L858R, respectively. MS9427 TFA selectively degrades the mutant but not the WT EGFR through both the ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways. MS9427 TFA potently inhibits the proliferation of NSCLC cells. MS9427 TFA can be used for researching anticancer; Target: EGFR;PROTACs
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