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Home Compound Library Sets Fight COVID19 libraries

Fight COVID19 libraries



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We at Chemspace want to contribute to the world’s fight against COVID-19 as much as we can. That is why we have selected 2 compound sets from our in-stock and make-on-demand parts of the database, both based on compounds that are experimentally or virtually active against SARS-CoV/SARS-CoV-2 proteases.

Please contact us at fight_covid19@chem-space.com for more details.

In the recent paper, a group of researchers from University of Basel published their results of ultra-large virtual screening of 687 Million Compounds against SARS-CoV-2 protease. They selected 11 drug-like hits with improved binding free energy to the target protease. We are ready to deliver 8 of 11 compounds and their nearest analogs for wet screening – please see the Part 1 Fight COVID2 set.
The Part 2 Fight COVID2 set consists of in-stock screening compounds similar or possessing the same Murcko scaffold as the experimentally active compounds for inhibition of SARS-CoV protease. The reference compounds were selected from PubChem and ChEMBL databases.

4-cyano-N-[3-(methanesulfinylmethyl)phenyl]pyridine-2-carboxamide
CSC160941837
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1-(6-{[(2-chloro-4-fluorophenyl)methyl]amino}-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one
CSC081324512
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N-(3-{[dimethyl(oxo)-λ⁶-sulfanylidene]amino}phenyl)-3-(piperidine-1-carbonyl)benzamide
CSC160963181
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5-tert-butyl-N-[(3-phenyl-1H-1,2,4-triazol-5-yl)methyl]thiophene-2-carboxamide
CSC160923606
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