G-protein coupled receptors (GPCRs) are a group of seven-domain transmembrane proteins that regulate many physiological processes and are accessible at the cell surface which makes them an attractive target for Drug Discovery. Nowadays, GPCRs have become increasingly popular among protein families for pharmacological targeting.
For facilitating afford in Drug Discovery linked to GPCRs, the Chemspace computational services team has created a library of compounds that target these receptors. Using a Ligand-Based Virtual Screening (LBVS) method called Ultrafast Shape Recognition with CREDO Atom Types (USRCAT), they selected structurally diverse compounds that share similar 3D molecular shapes without topological likeness.
GPCRs Targeted Pre-Plated Library includes over 8700 compounds selected from the initial Chemspace GPCRs Targeted Library (112K) based on their ability to show activity against targets that belong to 65 GPCR families.
Overall, the GPCRs Targeted Pre-Plated Library offers a valuable resource for researchers in the field of Medicinal Chemistry who are interested in developing drugs that target GPCRs. With its diverse set of compounds and efficient screening process, the library has the potential to accelerate Drug Discovery and improve understanding of GPCR-related physiological processes.
All compounds in the GPCRs Targeted Pre-Plated Library are dissolved in DMSO and provided by Enamine and UORSY, reliable world-renowned producers.
For more information about the set or enquiring, contact us at sales@chem-space.com.
