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Home Compound Library Sets Singleton Fragments

Singleton Fragments


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Fragment screening has been an important tool to generate new potent leads. The screening generates high-quality results (i.e. new starting points) if correct fragment library has been utilized. For Chemspace Singleton Fragments, we have utilized approaches that allow a) to cover wide chemical space: fragment-likeness and diversity selection, and b) bring novelty (molecules with new Murco frameworks).
Please contact us at info@chem-space.com for more details and if you are interested in the Make-on-Demand Singleton Fragments.

Compounds selection strategy:
- Comply Rule of 3, no PAINS and “toxic” moieties;
- New chemotypes (Tanimoto similarity to the nearest purchasable compound ≤ 0.45)
- Highly diverse set (Tanimoto similarity to the nearest compound within the set ≤ 0.5)
Availability:
- All compounds are in stock;
- Supplied as a full set or a cherry-picked selection;
- Formatting: powders, solutions (DMSO, 96-, 384-well plates)

2-[(1-methoxycyclobutyl)methyl]-3-methyl-1λ⁶,2-thiazolidine-1,1-dione
CSC102897315
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(8R,8aS)-8-methyl-hexahydrospiro[imidazo[4,3-c][1,4]oxazine-3,4'-thiane]-1-one
CSC093314750
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1-(1-methoxycyclopropanecarbonyl)-3-(propan-2-yl)azetidin-3-ol
CSC102890927
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1,1-difluoro-5-(4-methanesulfonylphenyl)-5-azaspiro[2.4]heptane
CSC063499049
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