Spirocyclic fragment contributes both to the rigidity and spherical form of the molecule. Moreover, further modification of the rings that are included in the spiro system expands the molecule in 3D. This enables high diversity of the analogs.
Discover Chemspace special Spiro Fragments set. All compounds in this set have at least 1 spiro moiety, accord with the Ro3, and are free of PAINS and toxic fragments.
|12||Heavy Atoms count||22||19|