Spirocyclic fragment contributes both to rigidity and spherical form of the molecule. Moreover, further modification of the rings that are included into the spirosystem expands the molecule in 3D. This enables high diversity of the analogs.
Discover Chemspace special Spiro Fragments set. All compounds in this set have at least 1 spiro moiety, accord with the Ro3 and are free of PAINS and toxic fragments.
![N-[(4-methyl-1H-1,3-benzodiazol-2-yl)methyl]-4-oxaspiro[bicyclo[3.2.0]heptane-6,1'-cyclobutane]-7-amine](/st/chem/200/27340000/27347683.png "N-[(4-methyl-1H-1,3-benzodiazol-2-yl)methyl]-4-oxaspiro[bicyclo[3.2.0]heptane-6,1'-cyclobutane]-7-amine")
![1-(3-fluoro-2-methylbenzenesulfonyl)-1-azaspiro[3.3]heptane](/st/chem/200/28260000/28265712.png "1-(3-fluoro-2-methylbenzenesulfonyl)-1-azaspiro[3.3]heptane")
![2-[1-(difluoromethyl)cyclopentanecarbonyl]-7-oxa-2-azaspiro[4.5]decane](/st/chem/200/74490000/74491403.png "2-[1-(difluoromethyl)cyclopentanecarbonyl]-7-oxa-2-azaspiro[4.5]decane")
![5-[(2-methoxyphenyl)methyl]-8-oxa-5-azaspiro[3.5]nonane](/st/chem/200/27780000/27785011.png "5-[(2-methoxyphenyl)methyl]-8-oxa-5-azaspiro[3.5]nonane")
| PhysChem Profile | |||
|---|---|---|---|
| Min | Max | Median | |
| 12 | Heavy Atoms count | 22 | 19 |
| 168 | MW | 300 | 271 |
| -0.2 | SlogP | 3.0 | 2.2 |
| 1 | HBA count | 3 | 3 |
| 0 | HBD count | 3 | 1 |
| 0 | RB count | 3 | 2 |
| 0.1 | fsp3 | 1.0 | 0.7 |
| 8 | TPSA | 82 | 46 |
| 2 | Rings count | 5 | 3 |
