Bicyclo[1.1.1]pentane is one of the smallest bicycle bridge systems. In the last couple of years, one can find this core in numerous drug discovery and medchem projects. That fact could be easily explained because bicyclo[1.1.1]pentane derivatives are bioisosteric to para-substituted benzenes; the cycle itself is small, highly strained, and quite polar, which often allows to increase solubility and decrease the toxicity of bicyclo[1.1.1]pentane-containing analogs. In fact, we present here only 7 compounds but you can always run a substructure search on https://chem-space.com/search or ask our team to find you bicyclo[1.1.1]pentane -containing molecules.

 

Interesting fact: K. Wiberg and F. Walker used dibromo bicyclo[1.1.1]pentane precursor to synthesize [1.1.1]propellane in 1982. Find bicyclo[1.1.1]pentane derivatives for your projects on Chemspace.com

 

Molecules of the week
3-aminobicyclo[1.1.1]pentane-1-carboxylic acid hydrochloride
CSC000761587
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2-[3-(methoxycarbonyl)bicyclo[1.1.1]pentan-1-yl]acetic acid
CSC009927489
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tert-butyl N-{3-aminobicyclo[1.1.1]pentan-1-yl}carbamate
CSC010883543
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tert-butyl N-({3-aminobicyclo[1.1.1]pentan-1-yl}methyl)carbamate
CSC011012513
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(2S)-2-amino-2-[3-(trifluoromethyl)bicyclo[1.1.1]pentan-1-yl]acetic acid hydrochloride
CSC020588799
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tert-butyl N-{[3-(hydroxymethyl)bicyclo[1.1.1]pentan-1-yl]methyl}carbamate
CSC011012366
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tert-butyl N-[3-(bromomethyl)bicyclo[1.1.1]pentan-1-yl]carbamate
CSC025778741
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