We are happy to continue our series of posts, which are inspired by Drug Hunter’s “Small Molecules of the Month”!
Here are two molecules that were recently highlighted by Drug Hunter!


1. SAR247799 is a G-protein-biased sphingosine-1-phosphate receptor 1 (S1P1) agonist that exhibits endothelial-protective properties and activates preferentially G-protein signaling over the β-arrestin and internalization pathways. The authors also investigated the potential of SAR247799 to improve cordial and renal functions of LVH metabolic syndrome and diastolic function in a rat model.

You can find the analogs to this molecule here!


2. IM156 is a selective mitochondrial protein complex 1 (PC1) inhibitor that plays a significant role in the modulation of oxidative phosphorylation (OXPHOS). This compound is a derivative of a biguanide molecule that was optimized from metformin and exhibits activity in lung fibrosis models. It is also suggested that metabolic and antifibrotic effects of IM156 can provide its testing as a therapy for IPS and other fibrotic diseases.

You can find the analogs to this molecule here!


Use chem-space.com/search to find off-the-shelf and Make-on-Demand molecules of your interest!

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