1. INE963 is an oral and fast-acting blood-stage antimalarial drug candidate. Potentially it can cure uncomplicated malaria in a single dose. INE963 was identified by a phenotype-based high-throughput screening (HTS) as one of a series of 5-aryl-2-amino-imidazothiadiazole (ITD) derivatives. It demonstrates potent cellular activity against Plasmodium falciparum (Pf 3D7) with “artemisinin-like” kill kinetics in vitro.
2. BMS-986176 (LX-9211) is a highly selective, CNS penetrant, potent AAK1 (adapter associated kinase 1) inhibitor, which is an example from a novel class of bi(hetero)aryl ethers. It showed excellent efficacy in rodent neuropathic pain models with excellent CNS penetration and target engagement at the spinal cord. BMS-986176 completed Phase I with good human PK and minimum adverse events and now is in Phase II for diabetic peripheral neuropathic pain.
Use chem-space.com/search to find off-the-shelf and Make-on-Demand molecules of your interest!
In case of any questions just drop us a line: firstname.lastname@example.org.