We are happy to continue our series of posts, which are inspired by Drug Hunter’s “Small Molecules of the Month”!
Here are two molecules that were recently highlighted by Drug Hunter!


1. INE963 is an oral and fast-acting blood-stage antimalarial drug candidate. Potentially it can cure uncomplicated malaria in a single dose. INE963 was identified by a phenotype-based high-throughput screening (HTS) as one of a series of 5-aryl-2-amino-imidazothiadiazole (ITD) derivatives. It demonstrates potent cellular activity against Plasmodium falciparum (Pf 3D7) with “artemisinin-like” kill kinetics in vitro.

You can find the analogs to this molecule here!


2. BMS-986176 (LX-9211) is a highly selective, CNS penetrant, potent AAK1 (adapter associated kinase 1) inhibitor, which is an example from a novel class of bi(hetero)aryl ethers. It showed excellent efficacy in rodent neuropathic pain models with excellent CNS penetration and target engagement at the spinal cord. BMS-986176 completed Phase I with good human PK and minimum adverse events and now is in Phase II for diabetic peripheral neuropathic pain.

You can find the analogs to this molecule here!


Use chem-space.com/search to find off-the-shelf and Make-on-Demand molecules of your interest!

In case of any questions just drop us a line: info@chem-space.com.