We are happy to continue our series of posts, which are inspired by Drug Hunter’s “Small Molecules of the Month”!
Here are two molecules that were recently highlighted by Drug Hunter!
1. M-1121 is a covalent and orally active inhibitor of the menin-MLL protein-protein interaction designed for the treatment of acute leukemia carrying MLL-rearrangements (MLLr leukemia). It forms covalent interactions with Cys329 from the MLL binding pocket of menin and inhibits expansion of acute leukemia cell lines with only MLL translocations.
You can find the analogs to this molecule here!
2. Compound 92a is an inhaled compound intended for pulmonary diseases, which shows dual pharmacology effects and laboring as M3 antagonist and PDE4 inhibitor (MAPI). It is an example of SAR optimization from two scaffold starting points that resulted in obtaining nanomolar activity for both M3 and PDE4.
You can find the analogs to this molecule here!
Use chem-space.com/search to find off-the-shelf and Make-on-Demand molecules of your interest!
In case of any questions just drop us a line: info@chem-space.com.
