Today George prepared a review of a crucial topic - anti-tuberculosis activity and structure-activity relationship (SAR) studies of oxadiazole derivates.   
Chemspace also offers you the chance to check out the 1,3,4-oxadiazole derivates set.

You can find the full list of molecules for exploration here!  

The development of new heterocycles that can fulfill the needs of modern Medicinal Chemistry remains a major task. The oxadiazole ring can be very useful due to being a bioisosteric substitution for carbonyl-containing functional groups like esters, amides, carbamates, etc. Besides, such compounds are relatively stable in biological media.   
Oxadiazoles also act as bioisosteric substitutions for the hydrazide moiety which can be found in first-line anti-TB drugs. The main mechanism of action of such drugs is causing cell wall disruption that leads to bacteria death. Specifically, the 1,3,4-oxadiazole-2-(3H)-thiones were revealed as in vitro anti-tubercular specialists against Mycobacterium tuberculosis.

Today’s featured article summarizes the development of oxadiazole-based derivatives with potential antituberculosis activity and bacteria discussing various aspects of the structure-activity relationship (SAR). Overall, oxadiazoles show promise as a new class of anti-tuberculosis drugs that could help combat the growing problem of drug-resistant tuberculosis.
The full text of the article is provided here!