Capmatinib (TABRECTA) approved by FDA in May 2020 for the treatment of non-small cell lung cancer. Capmatinib is an orally bioavailable inhibitor of the proto-oncogene c-Met (also known as hepatocyte growth factor receptor (HGFR)) with antineoplastic activity. It selectively binds to c-Met, inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. Capmatinib contains 2-fluoro-N-methylbenzamide moiety in its backbone.
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