A new co-authored article by our CEO Dr. Yurii Moroz and Director of Business Development Rita Gaidar is out!
Follow the link to check out the full publication.
The paper is dedicated to a new 2,3 derivatives of 4,5,6,7-tetrahydro-benzothio-phene as potent modulators of Retinoic acid receptor-related orphan receptor γt (RORγt). RORγt is a potential drug target for the treatment of inflammatory and auto-immune diseases. New modulators are soluble in acidic/neutral pH and demonstrate mouse/human/dog/rat microsomal stability. Also, the Drug Discovery approach reported in the article can be employed to find modulators of nuclear receptors and other globular protein targets.
We thank Ahmed Fouda, M.Sc., Sarita Negi, Oleg Zaremba, Eduard Rusanov, Steven Paraskevas, and Jean Tchervenkov for the productive collaboration!