We are thrilled to announce a new Chemspace co-authored article by our CEO, Dr. Yurii Moroz! Thanks to all authors for their great collaboration!    

Competitive chemoproteomic profiling is a powerful and widely used approach, especially for mapping ligandable cysteines. As a result, a chemoproteomic platform was developed for tyrosine and lysine. This platform uses a unique library of clickable and chiral SF probes and direct MS identification and quantification of probe-modified peptides. Thus, 634 stereoselectively modified sites (513 Tyr, 121 Lys) were identified by screening only ten enantiomeric pairs of SFs in living cells.   

This study provides a great resource of liganded sites and the first reported clickable covalent probes for most of the sites.  

Excellent work! Many thanks to all authors: Ying Chen, Gregory B. Craven, Roarke A. Kamber, Adolfo Cuesta, Serhii Zhersh, Yurii S. Moroz, Michael C. Bassik, and Jack Taunton!   

Full article you can find here.