This August, a group of researchers published an article 'Using sulfuramidimidoyl fluorides (SAFs) that undergo sulfur(vi) fluoride exchange for inverse drug discovery', that describes the study of a class of weak electrophiles SAFs, which undergo sulfur(vi) fluoride exchange chemistry. It is shown that binding of a SAF to a protein allows nucleophilic attack by a specific amino acid side chain, leading to conjugate formation.


Such fluorides form protein conjugates with cancer cells and covalently binds to and irreversibly inhibits the activity of poly(ADP-ribose) polymerase 1, an important anticancer target in living cells demonstraiting the usage of inverse drug discovery approach (IDD).


We at Chemspace selected the Covalent Modifiers library (In-Stock and Make-On-Demand), which can be used in the covalent docking and available for further purchasing.  In case of any questions just drop us a line: