This August, a group of researchers published an article 'Using sulfuramidimidoyl fluorides (SAFs) that undergo sulfur(vi) fluoride exchange for inverse drug discovery', that describes the study of a class of weak electrophiles SAFs, which undergo sulfur(vi) fluoride exchange chemistry. It is shown that binding of a SAF to a protein allows nucleophilic attack by a specific amino acid side chain, leading to conjugate formation.
Such fluorides form protein conjugates with cancer cells and covalently binds to and irreversibly inhibits the activity of poly(ADP-ribose) polymerase 1, an important anticancer target in living cells demonstraiting the usage of inverse drug discovery approach (IDD).
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