A great Sunday can become even better with a new article from George! 

So today we have a great topic for you – how cyclobutane ring affected the properties of selected drug candidates. Of course, at Chemspace we have a great selection of cyclobutane derivatives for you – don’t forget to check it out!

The unique 3D shape of cyclobutane opens a new door to its application in medicinal chemistry. Cyclobutanes have been employed for improving multiple factors such as preventing cis/trans-isomerization by replacing alkenes, replacing larger cyclic systems, increasing metabolic stability, directing key pharmacophore groups, inducing conformational restriction, reducing planarity, as aryl isostere, and filling hydrophobic pockets. 

The review we want to feature today focuses on the contributions of cyclobutane rings in drug candidates that lead them to favorable properties. The full text is available here.