Deubiquitinating enzymes (DUBs) are a family of peptidases that cleave ubiquitin from proteins and play a pivotal role in the pathogenesis of various diseases, including cancer, neurodegenerative disorders, and immune dysfunctions. They detach ubiquitin molecules from protein substrates or disassemble ubiquitin chains. This precise regulation by DUBs ensures the proper functioning of cellular processes and prevents the accumulation of ubiquitinated proteins that could lead to pathological states.


The future of DUB research is bright, with the anticipation of discovering safe and efficacious inhibitors for cancer therapy and beyond.

Biortus, as our reliable Biologics supplier, provides a diverse array of DUBs family members, including Ubiquitin-Specific Proteases (USPs), Ovarian Tumor Proteases (OTUs), and Ubiquitin Carboxyl-Terminal Hydrolases (UCHs). Leveraging cutting-edge technologies for protein preparation and structural analysis, Biortus ensures the highest standards of purity and functionality in its offerings, supporting researchers in uncovering DUBs' roles in diseases. 


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Chemspace | Deubiquitinating Enzymes Facilitate New Drug Development!