George is as excited about weekends as you are, so here is a new weekend article from him for you to enjoy!

For today’s post, we prepared a set of deuterium-containing compounds that you should check out! They are available here!


The use of deuteration in medicinal chemistry has exploded in the past years. It was boosted even more when the FDA approved the first drug with deuterium – deutetrabenazine

Deuteration of molecules affects pharmacokinetic parameters and might provide an opportunity when facing problems in terms of metabolism-mediated toxicity, drug interactions, and low bioactivation.


Today’s review mainly focuses on the recent developments of deuteration, deuterated clinical candidates, and highlights both opportunities and challenges of this strategy. To read the full text follow the link!