The article is a result of the great collaboration of the international team, in which our CEO Yurii Moroz took part.
It’s devoted to discovering new nonopioid analgesics from 301M REAL molecules in the ZINC15 library. Docking of virtual molecules to α2A-adrenergic receptor binding site and further structure determination led to the identification of selective agonists that show nanomolar activity without a sedative effect.
To check out the full text follow the link!
Many thanks to all for the great collaboration: Elissa A. Fink, Jun Xu, Harald Hübner, Joao M. Braz, Philipp Seemann, Charlotte Avet, Veronica Craik, Dorothee Weikert, Maximilian F. Schmidt, Chase M. Webb, Nataliya A. Tolmachova, Xi-Ping Huang, Chakrapani Kalyanaraman, Stefan Gahbauer, Geng Chen, Zheng Liu, Matthew P. Jacobson, John J. Irwin, Michel Bouvier, Yang Du, Brian K. Shoichet, Allan I. Basbaum, Peter Gmeiner.
If you are interested in our team’s publications, you can check them out by this link!
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