This October, the article 'Design, Synthesis, and Pharmacological Characterization of a Neutral, Non-Prodrug Thrombin Inhibitor with Good Oral Pharmacokinetics' describing research of small molecule thrombin inhibitors for the oral application was published.
Knowledge of the protein structure and the pregnane X receptor (PXR) helped to overcome a persistent cytochrome P450 3A4 induction problem. After successful design, synthesis, and testing, researches selected series "BAY 1217224" for further development.
This drug candidate contains 1,3-benzoxazole moiety in its backbone. We have made a set of compounds, which have such part – the perfect start for your research!