This September, the article 'Driving Potency with Rotationally Stable Atropisomers: Discovery of Pyridopyrimidinedione-Carbazole Inhibitors of BTK' describing discovery of a potent, reversible inhibitor of the Bruton's tyrosine kinase (BTK) "BMS-986143" was published.

Two rotationally stable atropisomeric axes in this compound provide a potent and selective single atropisomer with desirable efficacy and tolerability profiles against targets responsible for many autoimmune diseases.

"BMS-986143" contains 9H-carbazol moiety in its backbone. We have made a set of in-stock compounds, which have such part – the perfect start for your research!