Last year, a group of researchers published a review called “Next generation organofluorine blockbuster drugs”. This work highlights a section of most successful organo-fluorine drugs (eg. sitagliptin (diabetes), sofosbuvir (hepatitis C), emtricitabine (HIV)), their synthesis, and mode of action.
The emphasis is made on fluorine presence because it has been noticed to improve overall ADMET properties of the compounds like improving metabolic stability and increasing bioavailability.
We want to remind you that we at Chemspace have an amazing library of Fluorine fragments, containing high-quality small molecules with a single fluorine group in each. And all the molecules are in-stock!
To download the library you can use this link!