Last June, a group of researchers published a Perspective 'Fragment linking strategies for structure-based drug design'.
This exhaustive view describes usage of different approaches in fragment-based drug discovery (FBDD) - growing, linking, and merging - in design and synthesis of nearly 50 drugs and clinical candidates. The authors also showed that the realization of the super-additivity of fragments is challenging.
We at Chemspace offer 11 "In-Stock" Fragment Compound Sets, which can be used for the design and synthesis of screening compounds.
To browse the sets please use the link!
In case of any questions just drop us a line: info@chem-space.com.