Last June, a group of researchers published a Perspective 'Fragment linking strategies for structure-based drug design'.
This exhaustive view describes usage of different approaches in fragment-based drug discovery (FBDD) - growing, linking, and merging - in design and synthesis of nearly 50 drugs and clinical candidates. The authors also showed that the realization of the super-additivity of fragments is challenging.
We at Chemspace offer 11 "In-Stock" Fragment Compound Sets, which can be used for the design and synthesis of screening compounds.
To browse the sets please use the link!
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