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Today we want you to discover more about Heteroaromatic Diazirines in Medicinal Chemistry. We have also prepared a selected Diazirine Compound Set. Don’t forget to check it out!
The review highlights the synthesis of (3-trifluoromethyl)diazirine-substituted (TPD) heteroaromatics and their applications. Photoaffinity labeling (PAL) is used for attaching "labels" to the active site of a large molecule, especially a protein. PAL has also been demonstrated to identify ligand-binding biomolecules in a variety of drug-discovery fields. The selection of photophores is an important factor in the performance of an efficient photolabeling reaction. Also, heteroaromatic diazirines exhibit different physical properties to those of TPD, which may lead to breakthroughs in novel-polymer-material creation and other challenges.
