Hello to you from George!
Today he got inspired by a great article on the medicinal chemistry of isocyanides and prepared a compound set for you. It contains more than a thousand compounds containing this moiety.
You can browse the set here: https://chem-space.com/list/2f7285641ae74225965239a50ed931b8
Isocyanides are not considered typical warheads for medicinal chemistry projects, but today’s review has some arguments to argue with that!
The aim of the article is therefore to show the richness in the biological activity of the isocyanide-containing molecules, and to support the idea of using the isocyanide functional group as an unconventional pharmacophore especially useful as a metal coordinating warhead.
The unhidden hope is to convince skeptical medicinal chemists of the isocyanide potential in many areas of drug discovery and to consider them in the design of future drugs. To read the full article follow the link: https://pubs.acs.org/doi/full/10.1021/acs.chemrev.1c00143