Macrocycles are a powerful approach for any lead detection program against complex targets given their ability to cover large surface areas and influence polarity, which improves penetration through the membrane.

Chemspace Macrocyclic Compounds Library consists of 
254K macrocycles that are in-stock and available for purchase = compounds set + scaffolds of non-peptidic nature that could be further modified as well as totally assembled macrocyclic molecules.

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