Today George offers to check out our Macrocyclic Compounds Set and Macrocyclic Scaffolds!

These two great sets are available by this link.


Macrocyclic structures are often underestimated in the world of Drug Discovery, but their multiple functions and stereochemical complexity result in high affinity and selectivity to protein targets while maintaining sufficient bioavailability.   

Therefore, the construction of macrocycles is an ideal choice to solve the problem of “undruggable” targets.


Today’s article focuses on macrocyclic compounds used for anti-tumor purposes, their advantages and disadvantages, and the various synthetic methods for their synthesis. The authors hope, that this class of compounds will be further explored for anti-cancer treatment.  

To read the full article follow the link.