This July, a group of researchers published an article 'Non-Classical Phenyl Bioisosteres as Effective Replacements in a Series of Novel Open Source Antimalarials'. The paper describes the study of some analogs of phenyl group in a series of drug candidates against malaria. The results show that cubane and closo-carborane analogues exhibit improved in vitro potency while bicyclo[1.1.1]pentane (BCP) analogue is equipotent against Plasmodium falciparum (compared to the parent phenyl-containing compound). The former analogs show some changes in metabolic stability.
At Chemspace, we have selected two compound sets ("In-Stock" and "Make-On-Demand") with derivatives of cubane and BCP. To browse the sets, please use the following links:
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