Hope you are having a great weekend and we are here to make it even better with a new article from George!

Today’s topic is phosphonates, and a new compound set is already waiting for you here!


Compounds with a phosphonate group attached directly to the molecule via a P-C bond serve as suitable non-hydrolyzable phosphate mimics in various biomedical applications. In principle, they often inhibit enzymes utilizing various phosphates as substrates. The authors of today’s review focus on the past successes and prospects of phosphonate-containing prodrugs, with an emphasis on selected bioactive molecules.

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