Pyridones in Drug Discovery

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Home News Pyridones in Drug Discovery

9 July 2022

Pyridones in Drug Discovery

George is here with our traditional weekend article!

Today we have a relatively uncommon topic for discussion – pyridones. By the way, the dedicated set of 2000 selected compounds is already available for browsing! You can find it here!

Pyridones have been widely utilized in Drug Discovery. There are some features that exclusively interest scientists in these heterocycles:

- Ability to serve both as hydrogen bond acceptor and donor

- They can act as bioisosteres for amides, phenyls, pyridines, and other nitrogen- or oxygen-containing heterocycles

- They impact a target drug molecule’s lipophilicity, aqueous solubility, and metabolic stability

The review we are featuring today is giving a 20-year overview of the utilization of pyridones in the Drug Discovery process.

To read the full article follow the link.

Pyridones in Drug Discovery

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