Today George prepared for us a fascinating topic for our weekend article post – Quinoline derivates as scaffolds for medicinal and pharmaceutical chemistry! In addition, Chemspace picked a variety of selected compounds to form the Quinoline Compound Set!

In the past decade, a quinoline hybrid approach has been used for the identification of potential candidates for the treatment of many diseases. Today, the quinoline moiety gained attention for being an important part of the design, synthesis, and identification of novel potent compounds. The review we want to highlight today was written to shine a light on the critical biological activities of quinoline, such as anticancer (Irinotecan), antipsychotic (Aripiprazole), antimalarial (Chloroquine), antiviral (Saquinavir) and others. In addition, the authors discuss some classical and recent advances in quinoline synthesis methods. Here is the link to the full article!

This review is focused on quinoline and covers numerous areas like the synthesis approaches, clinical aspects of marketed drugs, in-vitro and in-vivo quinoline derivative data from the past 15 years, a recent advanced method of quinoline ring-closing reaction, biological activities, etc. We are sure you’ll like it!