George hopes that you all had a great Christmas and today he is here to present a new article to you! Today we are going to discuss how small molecules with chalcogen elements emerge as promising warheads for treating neglected tropical diseases.
For this post, we also created a selected set of sulfur-containing compounds with the substructures discussed in the article!
You can browse through it here!
As we get deeper into the development of new active compounds, a lot of authors try using more unusual combinations of atoms in search of novelty and new activities. Until a few decades ago, the focus of attention on chalcogens was on S and its derivatives, which over the years have been studied, developed, and commercialized for the treatment of multiple pathologies. Selenium and tellurium were banned for years, associated with toxicity, leaving aside their beneficial effects.
The authors state that new therapeutic effects of Se and Te were discovered in search of new therapeutic options. They review the types of scaffolds, activity, and biological effects of different chalcogen-containing compounds on three neglected tropical diseases.
The chemical versatility of S, Se, and Te is prominent in the search for new therapeutic alternatives, and we are looking forward to new discoveries! The full text of the article is available here.
.png)