Last month, a group of researchers published an article on the design and synthesis of novel spiro derivatives as potent and reversible Monoacylglycerol Lipase inhibitors (MAGL).

The authors used a structure-based drug discovery strategy to optimize an aromatic HTS hit to the final compound by replacing the binding site of the molecule with aliphatic moieties to improve activity and physicochemical properties.


Based on the article, we prepared a set of spirocyclic amides, that can become a great start for your research.

Bioisosteric replacements for aromatic fragments are on trend now!

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