Considering the outstanding properties of sulfoximines, this versatile functional group has advanced to implementation in several Drug Discovery programs. Currently, it can be found in various hit-to-lead and lead optimization studies in early stages and in several compounds currently in clinical trials. The review George prepared demonstrates the scope and limitations of sulfoximines in Medicinal Chemistry and Drug Discovery.

To read the full text: https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.0c00960 

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