Last October, a group of researchers published a study that describes usage of strategy to improve activity of amines and azoles through installation of N-trifluoromethyl group and investigation of their properties. Comparing the stability of N-trifluoromethyl amines and N-trifluoromethyl azoles in aqueous media showed that the latter compounds are stable, and the former ones are prone to hydrolysis. The authors also showed that the N-trifluoromethyl azoles have higher lipophilicity than N-methyl analogs and can show increased metabolic stability and Caco-2 permeability.

We at Chemspace have selected two sets with derivatives of N-trifluoromethyl-imidazole and N-trifluoromethyl-pyrazole.
To browse the sets, please use the following links:
The imidazole derivatives - 133 compounds.
The pyrazole derivatives - 1963 compounds.

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