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Search for Small Molecules by SMILES, name, CAS, MFCD, ID, InChI Key
Search for Biologics by ID, Target name, CAS, Protein name, Gene ID, Clone ID, Source Organism
Home Navigate in REAL and Freedom Spaces

REAL and Freedom Spaces: Search in both spaces simultaneously!
75%+ Synthetic Feasibility within 4-6 Weeks!

What is REAL Space?

It's a collection of 45 billion molecules REadily AccessibLe through validated parallel synthesis using Enamine in-stock building blocks and 161 validated synthesis protocols.

What is Freedom Space?

Freedom Space 3.0 is a unique space of 5 billion accessible molecules that was created using a combination of machine learning (ML) and the experience of medicinal chemists, based on the collection of in-stock building blocks from several suppliers and 10 well-validated chemical transformations.

Are all the compounds available?

The compounds are made on demand and the success rate is above 75% with a synthesis time of 3-5 weeks. This is possible due to the careful selection of reliable reaction protocols and in-stock building blocks, which were used to build the space.

What is infiniSee?

It's an app, which you can install locally on your PC. It contains the same 50 billion molecules, but the search runs behind your firewall. Use the advanced infiniSee tool to get even more from the search.

Why can't I search by Substructure?

The space is built from chemical reactions and compatible building blocks. Currently, substructure searching is not in the scope of supported functionalities. But you can search for any molecule containing the substructure of interest and filter the results for exact matches afterwards.

Can I download the space files?

Yes, from BioSolveIT. But please keep in mind that this is not a classical SD file, which is impossible for 50 billion compounds. You will need the suitable search algorithm, as e.g. in infiniSee to explore it.

How does the search work?

The search works via similarity to a user-given query or template molecule. The search algorithm (Feature Trees) represents a molecule in a fuzzy way. This allows you to find either close chemical analogues of your query or scaffold hops to structurally diverse compounds sharing the same pharmacophore properties. A little explanatory video can be found here.

What is the expected delivery time?

Synthesis time is 3-5 weeks depending on the set size and complexity of the synthesis. Depending on the shipping time, you may expect the final screening compounds to arrive at your bench within approximately 4-6 weeks. Synthesis success rate lies above 75%.

Why should I search in REAL and Freedom Spaces?

Navigation in REAL and Freedom Spaces is great for efficient hit exploration, from finding previously unknown analogs to scaffold hopping. Exceptional scaffold hopping capabilities of our search engine allow you to explore IP free areas as well as solve existing practical problems in drug discovery related to physicochemical properties, metabolic stability, toxicity etc.