REAL and Freedom Spaces: Search in both spaces simultaneously!
75%+ Synthetic Feasibility within 4-6 Weeks!

It's a collection of 70 billion molecules REadily AccessibLe through validated parallel synthesis using Enamine in-stock building blocks and 167 validated synthesis protocols.

Freedom Space 3.0 is a unique space of 5 billion accessible molecules that was created using a combination of machine learning (ML) and the experience of medicinal chemists, based on the collection of in-stock building blocks from several suppliers and 10 well-validated chemical transformations.

The compounds are made on demand and the success rate is above 75% with a synthesis time of 3-5 weeks. This is possible due to the careful selection of reliable reaction protocols and in-stock building blocks, which were used to build the space.

It's an app, which you can install locally on your PC. It contains the same 76 billion molecules, but the search runs behind your firewall. Use the advanced infiniSee tool to get even more from the search.

The space is built from chemical reactions and compatible building blocks. Currently, substructure searching is not in the scope of supported functionalities. But you can search for any molecule containing the substructure of interest and filter the results for exact matches afterwards.

Yes, from BioSolveIT. But please keep in mind that this is not a classical SD file, which is impossible for 76 billion compounds. You will need the suitable search algorithm, as e.g. in infiniSee to explore it.

The search works via similarity to a user-given query or template molecule. The search algorithm (Feature Trees) represents a molecule in a fuzzy way. This allows you to find either close chemical analogues of your query or scaffold hops to structurally diverse compounds sharing the same pharmacophore properties. A little explanatory video can be found here.

Synthesis time is 3-5 weeks depending on the set size and complexity of the synthesis. Depending on the shipping time, you may expect the final screening compounds to arrive at your bench within approximately 4-6 weeks. Synthesis success rate lies above 75%.

Navigation in REAL and Freedom Spaces is great for efficient hit exploration, from finding previously unknown analogs to scaffold hopping. Exceptional scaffold hopping capabilities of our search engine allow you to explore IP free areas as well as solve existing practical problems in drug discovery related to physicochemical properties, metabolic stability, toxicity etc.