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Home Navigate in REAL Space

Navigate in REAL Space


What is REAL space?

It’s the world's largest collection of commercially available compounds containing 11billion – precisely 11,132,721,451 – molecules. The chemical space is based on 121 Enamine synthesis protocols and in-stock building blocks.

Are all the compounds real?

The compounds are made on demand and the success rate is above 80 % with a synthesis time of 3 weeks. This is possible due to the careful selection of reliable reaction protocols and in-stock building blocks, which were used to build the space.

What is REAL Space Navigator?

It’s an app, which you can install locally on your PC. It contains the same 11 billion molecules, but the search runs behind your firewall. Using the REAL Space Navigator App you do not have to reveal your query molecule on the internet.

Why can't I search by Substructure?

The space is a build from chemical reactions and compatible building blocks. Currently substructure searching is not in the scope of supported functionalities. But you can search for any molecule containing the substructure of interest and filter the results for exact matches afterwards.

Are REAL space and REAL DB the same?

No. Whilst the REAL DB is a manual collection of compounds the REAL Space is a combinatorial exploration of all possibilities. And the Space with it’s 11 billion compounds is orders of magnitude bigger than the REAL DB, which contains 720 million compounds.

Can I download the space?

Yes, from BioSolveIT. But please keep in mind that this is not a classical SD file, which is impossible for 11 billion compounds. You will need the suitable search algorithm, as e.g. in infiniSee to explore it.

How does the search works?

The search works via similarity to a user-given query or template molecule. The search algorithm (Feature Trees) represents a molecule in a fuzzy way. This allows you to find either close analogues of your query or scaffold hops to structurally diverse compounds sharing the same pharmacophore properties. A little explanatory video can be found here.

What is the expected delivery time?

Synthesis time is less than 3 weeks. Depending on the shipping time, you may expect the compounds to arrive at your bench within approximately 4 weeks. Our success rate lies above 80%.