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IUPAC Name:(2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-N-[(1r,3s)-3-hydroxy-3-methylcyclobutyl]-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide
Supplier Lead time Price, $ Pack Targetmol Chemicals IncShips from: United StatesTo:30 days 1,820 Description: MI-888 is a potent MDM2 inhibitor (Ki = 0.44 nM) with a superior pharmacokinetic profile and enhanced in vivo efficacy. MI-888 is capable of achieving rapid, complete, and durable tumor regression in two types of xenograft models of human cancer with oral administration and represents the most potent and efficacious MDM2 inhibitor reported to date.; CAS: 1303607-59-1MedChemExpressShips from: United StatesTo:TBD POA1 mgDescription: Names: MI-888; Product Description: MI-888 is an orally active MDM2 inhibitor with a K i of 0.44 nM. MI-888 can inhibit the MDM2-p53 interaction. MI-888 has favorable pharmacokinetic properties and anti-tumor activity .; Target: MDM-2/p53; CAS: 1303607-59-1For a custom pack size or bulk
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IUPAC Name:5-chloro-1'-(2-{[3-(hydroxymethyl)-2-oxo-1-[(1r,3s)-3-hydroxy-3-methylcyclobutyl]-7-(trifluoromethyl)-2,3-dihydro-1H-1,3-benzodiazol-5-yl]oxy}ethyl)-1,2-dihydrospiro[indole-3,4'-piperidin]-2-one
Supplier Lead time Price, $ Pack MedChemExpressShips from: United StatesTo:TBD POA1 mgDescription: Names: APOL1-IN-2; Product Description: APOL1-IN-2 (Compound 467) is the inhibitor for Apolipoprotein 1 ( APOL1 ). APOL1-IN-2 reduces the APOL1 G2/G1 induced cell death in HEK293 with EC 50 of 4.74 nM and 14.3 nM. APOL1-IN-2 reduces the APOL1 G2/G1/G0 induced death of trypanosomes with EC 50 of 2.24, 6.03 and 3.72 nM, respectively .; Target: Apolipoprotein; CAS: 2956781-84-1MedChemExpress EUShips from: SwedenTo:TBD POA1 mgDescription: Names: APOL1-IN-2; Product Description: APOL1-IN-2 (Compound 467) is the inhibitor for Apolipoprotein 1 (APOL1). APOL1-IN-2 reduces the APOL1 G2/G1 induced cell death in HEK293 with EC50 of 4.74 nM and 14.3 nM. APOL1-IN-2 reduces the APOL1 G2/G1/G0 induced death of trypanosomes with EC50 of 2.24, 6.03 and 3.72 nM, respectively; Target: Apolipoprotein; CAS: 2956781-84-1Targetmol Chemicals IncShips from: United StatesTo:TBD POA1 mgDescription: APOL1-IN-2 (Compound 467) acts as an inhibitor of apolipoprotein L1 (APOL1). It effectively reduces HEK293 cell death induced by APOL1 G2/G1, with EC50 values of 4.74 nM and 14.3 nM, respectively. Additionally, APOL1-IN-2 decreases the mortality of trypanosomes triggered by APOL1 G2/G1/G0, with EC50 values of 2.24, 6.03, and 3.72 nM, respectively.; CAS: 2956781-84-1For a custom pack size or bulk
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