The presence of modification points in the FBDD hits enables their further developability and/or combining of the different hits in one larger molecule. Please also discover our Acid Fragments set that contains compounds with at least one modifiable carboxylic group.
Chemspace Amine Fragments is a set of small polar molecules containing at least one primary or secondary amino group. We selected fragment-like compounds that have high fsp3 and moderate TPSA and are convenient for further modification and fragment follow-up.
For any questions contact us at [email protected]
![Chemical structure of 3-(1-methyl-1H-pyrazol-5-yl)-8-azabicyclo[3.2.1]oct-2-ene - CSSS00000728496](/st/structure/200/801e3bf05e0ee7fa8b575a07503c1b65/CN1N%253DCC%253DC1C1%253DCC2CCC%2528C1%2529N2.png)
![Chemical structure of N-{octahydrocyclopenta[b]pyrrol-3a-yl}-1H-pyrrolo[3,2-b]pyridine-5-carboxamide - CSSS00138509932](/st/structure/200/d5991621a9a80214463245978f3b79d2/O%253DC%2528NC12CCCC1NCC2%2529C1%253DCC%253DC2NC%253DCC2%253DN1.png)
| PhysChem Profile | |||
|---|---|---|---|
| Min | Max | Median | |
| 11 | Heavy Atoms count | 22 | 19 |
| 151 | MW | 300 | 268 |
| -1.4 | SlogP | 3 | 1.9 |
| 1 | HBA count | 3 | 3 |
| 1 | HBD count | 3 | 1 |
| 0 | RB count | 3 | 3 |
| 0.1 | fsp3 | 1 | 0.5 |
| 12 | TPSA | 91 | 42 |
| 1 | Rings count | 5 | 2 |
