We are happy to continue our series of posts, which are inspired by Drug Hunter’s “Small Molecules of the Month”!
Here are two molecules that were recently highlighted by Drug Hunter!


1. ABBV-318 is an oral, selective, and CNS-penetrant inhibitor of two sodium channel isoforms - Nav1.7/Nav1.8. These voltage-gated sodium channels are known as attractive targets for pain treatment, which is highly validated with genetic evidence in humans. ABBV-318 was identified from structure-activity relationship (SAR) studies of 2-substituted quinolines and quinolones as starting points. It demonstrates higher potency, improved hERG channel selectivity, and better phospholipidosis overcoming.

You can find the analogs to this molecule here!


2. ‘Compound 53’ is a non-nucleotide stimulator of interferon genes (STING) agonist. It promotes the oligomerization and activation of human STING with mechanism, that orthogonal to cGAMP. STING is an adaptor protein in inborn immunity against DNA viruses or bacteria. STING-mediated immunity could be exploited in the development of vaccines or cancer immunotherapies.

You can find the analogs to this molecule here!


Use chem-space.com/search to find off-the-shelf and Make-on-Demand molecules of your interest!

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