We are happy to continue our new inspired by Drug Hunter’s “Small Molecules of the Month” series!

Here are three molecules that were recently highlighted by Drug Hunter!

Using Chemspace will allow you to get off-the-shelf and synthetic analogs to these compounds.

1. Atabecestat (“JNJ-54861911”) is the first thiazine-based BACE1 aspartyl protease inhibitor. It was a promising oral, brain-penetrant drug candidate for the treatment of preclinical Alzheimer’s disease (AD), identified from both phenotypic HTS and SBDD.

You can find the analogs to this molecule here!

2. Enpatoran (“M5049”) is an orally active, selective inhibitor of two toll-like transmembrane receptors TLR7 and TLR8. Abnormal TLR7/8 activation is potentially pathogenic and connected to progress of distinct autoimmune diseases. Now this candidate is in Phase I trial for Lupus.

You can find the analogs to this molecule here!

3.“NITD-688” is the first antiviral preclinical candidate, showed strong potency against all four serotypes of Dengue virus (DENV) in mice. It demonstrated excellent oral bioavailability and long elimination half-life. “NITD-688” was identified via high-throughput phenotypic (HTP) screening of 1.5M Novartis compound library.

You can find the analogs to this molecule here!

Use chem-space.com/search to find analogs for your molecules of interest!