We are happy to continue our series of posts, which are inspired by Drug Hunter’s “Small Molecules of the Month”!
Here are two molecules that were recently highlighted by Drug Hunter!


1. TAK-653 is a positive allosteric modulator of AMPA receptor which shows little agonistic effects and works as an enhancer for synaptic and cognitive function. It bounds to the ligand-binding domain of AMPA-R similar to glutamate and precisely potentiated a glutamate-induced Ca2+ influx in cells.

You can find the analogs to this molecule here!


2. Compound 59 is a brain penetrant, selective inhibitor of the adaptor protein 2-associated kinase 1 (AAK1) that is known as a potential therapeutic target for neuropathic pain. It is an example of SAR optimization of a series of aryl amide-based AAK1 inhibitors that display efficacy in models for persistent and chronic-constriction-injury-induced pain.

You can find the analogs to this molecule here!


Use chem-space.com/search to find off-the-shelf and Make-on-Demand molecules of your interest!

In case of any questions just drop us a line: info@chem-space.com.