Discover Chemspace meta-Substituted Benzene Bioisosteres – a library of 260 in-stock compounds that can mimic phenyl ring properties and potentially enhance physicochemical and pharmacokinetic characteristics of molecules in the drug development process.

The benzene ring is the most spread in commercially available drugs and compounds under clinical trials. Numerous detailed analyses of compound properties have shown that the presence of flat phenyl rings in molecules is a crucial factor contributing to unfavorable properties in molecules facing drug development challenges.

These observations have inspired the elaboration of potential bioisosteric replacements for disubstituted benzene rings that could lead to improved molecule lipophilicity and solubility, provide molecules with better ADME profiles, and generate patentable compounds.

Drop us a line if you have any questions: info@chem-space.com